Abstract
The C(sp3)–C(sp3) bond is one of the most prevalent motifs in organic compounds and holds significant
importance in organic synthesis. The utilization of two alkyl electrophiles for cross-coupling
stands as a vital strategy in building C(sp3)–C(sp3) bonds. Nowadays, synthetic electrochemistry is undergoing rapid development owing
to its exceptional attributes not only in terms of green and economic properties by
reducing the large amount of traditional chemical reductants, but also by its capacity
to generate highly reactive radical intermediates under mild conditions, thereby opening
up new reaction pathways and presenting novel opportunities to constructing C(sp3)–C(sp3) bonds. This article aims to comprehensively delineate the historical development
of traditional electrophilic reagents in constructing C(sp3)–C(sp3) bonds, while also delving into the advantages of electrochemical electrophilic cross-coupling
in this domain.
1 Introduction
2 Case Studies of Nickel-Catalyzed and Photochemical Alkyl Halide Cross-Coupling
3 Case Studies of Electrocatalyzed Approaches for the Construction of C(sp3)–C(sp3) Bonds Using Electrophilic Reagents
4 Nickel-Electrocatalyzed C(sp3)–C(sp3) Cross-Coupling of Unactivated Alkyl Halides
5 Conclusion
Key words
electrophilic reagents - cross-coupling - organic electrosynthesis - C(sp
3)–C(sp
3) bonds - nickel catalysis